Which herb contains hypericin and hyperforin and is commonly used for depression and anxiety?

• A. Iris versicolor
• B. Hypericum perforatum
• C. Lavandula angustifolia
• D. Leonurus cardiaca

Answer: (B)

St. John’s wort, Hypericum perforatum, is the herb that contains the active constituents hypericin and hyperforin and is commonly used for depression and anxiety. These compounds are thought to help regulate mood by modulating monoamine neurotransmitters in the brain, particularly increasing serotonin, norepinephrine, and dopamine activity through effects on reuptake and receptor signaling. Clinically, this makes it a go-to option for mild to moderate depression and associated anxiety when appropriate, often as part of a broader treatment plan.

Be mindful that this herb can interact with many medications by inducing liver enzymes, which can reduce the effectiveness of birth control pills, anticoagulants, and various other drugs, and it can cause photosensitivity in some people. It’s important to use it under professional guidance if you’re taking other medications or have health conditions.

The other herbs listed do not contain hypericin or hyperforin and aren’t the classic mood-supporting options tied to those constituents. Iris versicolor is used for other conditions, lavender is valued for calming effects but not for these plant compounds, and motherwort has different traditional uses.